ABSTRACT
Oral Ketamine is used as a low side effect analgesic in comparison with opioids, in different pain syndromes. This study is designed to evaluate the effect of oral Ketamine in renal colic treatment. In this clinical trial study 104 patients with renal colic, hospitalized in emergency department, were divided into two groups by Random block design. Group B received Pethidine [1 mg/kg up to 100 mg] and placebo, and group A received Pethidine with the same dose and Ketamine [0.5 mg/kg]. All patients were assessed for pain by using VAS chart, for nausea by a 0-3 scale and for the number of vomiting; at baseline and 1, 2 and 3 hours after taking drug. The results were analyzed by t-test. Average pain score and vomiting in all times and nausea score in one and three hours after receiving drugs were reduced significantly in patients who took Pethidine and Ketamine comparing patients who took Pethidine and placebo[p < 0.05]. Regarding the significant effect of Ketamine in reduction of pain, nausea and vomiting without side effects, it is possible to use Ketamine as an adjuvant drug in treatment of renal colic and to reduce narcotic dosage